Nakajima-Takagi Y, Andoh S, Fukuta T, Miyota M, Tsuchiya A, Koide S, Oshima M, Nannya Y, Hayashi Y, Harada H, Iwama A. Inflammasome activation promotes the progression of myelodysplastic syndrome. 第22回幹細胞シンポジウム，淡路，5月，2025
Ashihara E, Hadate Y, Hattori Y, Hayashi Y, Toda Y, Hosogi S, Okada S. A Novel Dipetide Type Inhibitor of Wnt/β-catenin Pathway Suppressed Proliferation of Acute Myelogenous Leukemia. 第15回 日本血液学会 国際シンポジウム，佐賀，5月，2025
2024年
学術論文
Hayashi Y*（責任著者）, Kamimura-Aoyagi Y, Nishikawa S, Noka R, Iwata R, Iwabuchi A, Watanabe Y, Matsunuma N, Yuki K, Kobayashi H, Harada Y, Harada H*（責任著者）. IL36G-producing neutrophil-like monocytes promote cachexia in cancer. Nature Communications 15(1):7662, 2024
Matsunuma N, Hayashi Y*（責任著者）, Fukuda M, Yuki K, Kamimura-Aoyagi Y, Kobayashi H, Shingai N, Harada Y, Harada H*（責任著者）. HMGA2 promotes platelet-neutrophil complex formation and pulmonary tissue damage in myelodysplastic syndromes. Blood Vessels, Thrombosis & Hemostasis 1(2):100014, 2024
Kobayashi H, Komizo Y, Watanabe N, Kamimura-Aoyagi Y, Yuki K, Hayashi Y, Yoshida M, Harada Y, Harada H. Identification of a drug candidate for anti-thrombocytopenia in myelodysplastic syndromes. 第86回日本血液学会学術総会, 京都, 10月, 2024
Andoh S, Nakajima-Takagi Y, Fukuta T, Miyota M, Tsuchiya A, Koide S, Oshima M, Hayashi Y, Harada H, Iwama A. Inflammasome activation promotes the progression of MDS. 第86回日本血液学会学術集会, 京都, 10月, 2024
Hayashi Y and Harada H. Mitochondrial dynamics as a pathobiological mediator of clonal myeloid disorders. Cancer Science 14(7):2722-2728, 2023.
Ikeda N, Kubota H, Suzuki R, Morita M, Yoshimura A, Osada Y, Kishida K, Kitamura D, Iwata A, Yotsumoto S, Kurotaki D, Nishimura K, Nishiyama A, Tamura T, Kamatani T, Tsunoda T, Murakawa M, Asahina Y, Hayashi Y, Harada H, Harada Y, Yokota A, Hirai H, Seki T, Kuwahara M, Yamashita M, Shichino S, Tanaka M, Asano K. The early neutrophil-committed progenitors aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis. Cell Reports 42(3):112165, 2023
Takase S, Hiroyama T, Shirai F, Maemoto Y, Nakata A, Arata M, Matsuoka S, Sonoda T, Niwa H, Sato S, Umehara T, Shirouzu M, Nishigaya Y, Sumiya T, Hashimoto N, Namie R, Usui M, Ohishi T, Ohba S, Kawada M, Hayashi Y, Harada H, Yamaguchi T, Shinkai Y, Nakamura Y, Yoshida M, Ito A. A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression. Nature Communications 14(1):23, 2023
Nomura K, Harada Y, Kamimura-Aoyagi Y, Matsunuma N, Mori K, Izumi A, Komizo Y, Kobayashi H, Hayashi Y, Hijikata A, Doki N, Hagihara M, Gotoh A, Harada H. Utility of mitochondria dynamics to differentiate myelodysplastic syndromes from other cytopenic conditions. 第82回日本癌学会学術総会, 横浜, 9月, 2023
Kamimura-Aoyagi Y, Harada Y, Nomura K, Matsunuma N, Mori K, Izumi A, Komizo Y, Kobayashi H, Hayashi Y, Hijikata A, Doki N, Hagihara M, Gotoh A, Harada H. Diagnosis of myelodysplastic syndromes based on mitochondria dynamics abnormalities. 第85回日本血液学会学術集会, 東京, 10月, 2023
Aoyagi Y, Hayashi Y*（責任著者）, Harada Y, Choi K, Matsunuma N, Sadato D, Maemoto Y, Ito A, Yanagi S, Starczynowski DT, Harada H. Mitochondrial Fragmentation Triggers Ineffective Hematopoiesis in Myelodysplastic Syndromes. Cancer Discovery. 12(1): 250-269, 2022
Hayashi Y, Harada Y, Harada H. Myeloid neoplasms and clonal hematopoiesis from the RUNX1 perspective. Leukemia 36(5): 1203–1214, 2022
Kamachi K, Ureshino H, Watanabe T, Yoshida N, Yamamoto Y, Kurahashi Y, Fukuda-Kurahashi Y, Hayashi Y, Hirai H, Yamashita S, Ushijima T, Okada S, Kimura S. Targeting DNMT1 by demethylating agent OR-2100 increases tyrosine kinase inhibitors-sensitivity and depletes leukemic stem cells in chronic myeloid leukemia. Cancer Letters. 526: 273-283, 2022
松沼菜摘, 林嘉宏, 青栁泰成, 新谷直樹，原田結花, 原田浩徳. HMGA2 promotes the platelet-neutrophil complexes formation and causes organizing pneumonia in myelodysplastic syndromes. 第81回日本癌学会学術総会，横浜，9月，2022
林嘉宏, 松沼菜摘，青栁泰成，新谷直樹，原田結花, 原田浩徳. HMGA2-mediated platelet activation promotes neutrophil death and causes organizing pneumonia in MDS. 第84回日本血液学会学術集会，福岡，10月，2022
Ikeda N, Iwata A, Kamatani T, Tsunoda T, Hayashi Y, Harada H, Harada Y, Tanaka M, Asano K. Identification of differentiation pathway for neutrophil-like monocytes during emergency hematopoiesis. 第51回日本免疫学会学術集会，熊本，12月，2022
2021年
学術論文
Ureshino H, Kurahashi Y, Watanabe T, Yamashita S, Kamachi K, Yamamoto Y, Fukuda-Kurahashi Y, Yoshida-Sakai N, Hattori N, Hayashi Y, Kawaguchi A, Tohyama K, Okada S, Harada H, Ushijima T, Kimura S. Silylation of Deoxynucleotide Analog Yields an Orally Available Drug with Antileukemia Effects. Molecular Cancer Therapeutics. 20(8): 1412-1421, 2021
林嘉宏, 青栁泰成, 松沼菜摘, 貞任大地，原田結花, 原田浩徳. Excessive mitochondrial fragmentation as a fundamental trigger of ineffective hematopoiesis in MDS. 第83回日本血液学会学術集会，Web開催，9月，2021