研究業績

2011 - 2015

 

2015年

学会発表

  1. Hayashi Y, Zhang Y, Yan X, Choi K, Sashida G, Xu Z, Wu L, Harada H, Shih LY, Tse W, Witte D, Caligiuri M, Wang QF, Xiao Z, Huang G. Identification and Targeting HIF-1α pathway in MDS development and maintenance. The 13th International Symposium on Myelodysplastic Syndromes, Washington D.C., USA, 5月, 2015
  2. Hayashi Y, Yan X, Jordan MB, Filipovich AH, Huang G. New Mechanisms of HLH Pathogenesis Revealed from A Novel Mouse Model. 31st Annual Meeting of the Histiocyte Society, Athens, Greece, 9月, 2015
  3. Hayashi Y, Yan X, Xiao Z, Huang G. High HIF-1α level results in murine MDS/MPN or HLH in different mouse backgrounds. 44th International Society for Experimental Hematology Annual Scientific Meeting, Kyoto, Japan, 9月, 2015
  4. Yokota A, Hirai H, Hayashi Y, Tamura A, Sato A, Iwasa M, Fujishiro A, Shoji T, Miura Y, Maekawa T. IFNα promotes differentiation of BCR-ABL+ leukemic cells through upregulating C/EBPβ. 44th International Society for Experimental Hematology Annual Scientific Meeting, Kyoto, Japan, 9月, 2015
  5. Hayashi Y, Zhang Y, Yan X, Choi K, Sashida G, Dong Y, Xu Z, Wu L, Chen A, Sun X, Olsson HA, Harada H, Shih LY, Tse W, Bridges JP, Witte D, Wang QF, Caligiuri M, Grimes HL, Nimer SD, Xiao Z, Huang G. HIF-1α pathway is essential and sufficient for MDS development as a signal funnel for genetic, epigenetic, and metabolic aberrations. 57th ASH Annual Meeting and Exposition, Orlando, FL, USA, 12月, 2015
  6. Dong Y, Hayashi Y, Yan X, Xue F, Chen W, Huang G. Two Novel Knock-in and Knock-out of Setd2 Alleles Cooperate with Mll-Af9 Knock-in Allele to Accelerate Leukemia Development. 57th ASH Annual Meeting and Exposition, Orlando, FL, USA, 12月, 2015
  7. Wang J, Hayashi Y, Xu Z, Wu L, Yan X, Kalfa TA, Xiao Z, Huang G. Activation of HIF-2a-EPO Axis in Kidney or Liver Is Sufficient to Drive Erythrocytosis in a Novel Inducible HIF-2a Transgenic Mouse Model. 57th ASH Annual Meeting and Exposition, Orlando, FL, USA, 12月, 2015

 

2014年

学術論文

  1. Zhao X, Chen A, Yan X, Zhang Y, He F, Hayashi Y, Dong Y, Rao Y, Li B, Conway RM, Maiques-Diaz A, Elf SE, Huang N, Zuber J, Xiao Z, Tse W, Tenen DG, Wang Q, Chen W, Mulloy JC, Nimer SD, Huang G. Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal. Blood 123(11): 1729-1738, 2014
  2. Sashida G, Harada H, Matsui H, Oshima M, Yui M, Harada Y, Tanaka S, Mochizuki-Kashio M, Wang C, Saraya A, Muto T, Hayashi Y, Suzuki K, Nakajima H, Inaba T, Koseki H, Huang G, Kitamura T, Iwama A*. Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation. Nature Communications, 5:4177, 2014
  3. Yao H, Miura Y, Yoshioka S, Miura M, Hayashi Y, Tamura A, Iwasa M, Sato A, Hishita T, Higashi Y, Kaneko H, Ashihara E, Ichinohe T, Hirai H, Maekawa T. Parathyroid hormone enhances hematopoietic expansion via upregulation of cadherin-11 in bone marrow mesenchymal stromal cells. Stem Cells 32(8): 2245-2255, 2014
  4. Yoshioka S, Miura Y, Yao H, Satake S, Hayashi Y, Tamura A, Hishita T, Ichinohe T, Hirai H, Takaor-Kondo A, Maekawa T. CCAAT/enhancer-binding protein β expressed by bone marrow mesenchymal stromal cells regulates early B-cell lymphopoiesis. Stem Cells 32(3): 730-740, 2014

学会発表

  1. Hayashi Y, Zhang Y, Yan X, Sashida G, Xu Z, Harada H, Xiao Z, Huang G. Modeling and Targeting MLL-PTD/RUNX1 Related MDS/AML in Mouse. The 43rd International Society for Experimental Hematology Annual Scientific Meeting, Montreal, Canada, 8月, 2014
  2. 横田明日美, 平位秀世, 林嘉宏, 田村彰広, 佐藤淳至, 八尾尚幸, 岩佐麿佐紀, 藤城綾, 三浦康生, 前川平. BCR－ABL発現白血病細胞に対するC/EBPβを介したIFNαの作用. 第73回日本癌学会学術総会,横浜, 9月, 2014
  3. Sato A, Hirai H, Tamura A, Yokota A, Hayashi Y, Yao H, Yoshioka S, Iwasa M, Miura Y, Maekawa T. C/EBPβ promotes initial expansion and exhaustion of hematopoietic stem cells in response to stresses. 第76回日本血液学会学術集会,大阪, 10月, 2014
  4. Yokota A, Hirai H, Hayashi Y, Tamura A, Sato A, Yao H, Yoshioka S, Iwasa M, Miura Y, Maekawa T. Involvement of C/EBP β in IFN α-induced differentiation of BCR-ABL-expressing leukemic cells. 第76回日本血液学会学術集会,大阪, 10月, 2014
  5. Hayashi Y, Zhang Y, Yan X, Sashida G, Xu Z, Dong Y, Harada H, Xiao Z, Huang G. Novel myelodysplastic syndromes-like mouse models by cooperating genetic/epigenetic mutations reveal the critical role of HIF-1α for disease development. 56th ASH Annual Meeting and Exposition, San Francisco, CA, USA, 12月, 2014

 

2013年

学術論文

  1. Satake S, Hirai H, Hayashi Y（共同第一著者）, Shime N, Tamura A, Yao H, Yoshioka S, Miura Y, Inaba T, Fujita N, Ashihara E, Imanishi J, Sawa T, Maekawa T. C/EBPβ is involved in the amplification of early granulocyte precursors during candidemia-induced "emergency" granulopoiesis. The Journal of Immunology 189(9): 4546-4555, 2012
  2. Hayashi Y, Hirai H, Kamio N, Yao H, Yoshioka S, Miura Y, Ashihara E, Fujiyama Y, Tenen DG, Maekawa T. C/EBPβ promotes BCR-ABL-mediated myeloid expansion and leukemic stem cell exhaustion. Leukemia 27(3): 619-628, 2013

学会発表

  1. Hayashi Y, 平位秀世, 横田明日美, 八尾尚幸, 三浦康生, 芦原英司, 前川平. 転写因子C/EBPβは骨髄系分化・増殖の誘導によりCML幹細胞を減少させる. 第17回日本がん分子標的治療学会学術総会, 京都, 6月, 2013
  2. Yao H, Miura Y, Yoshioka S, Iwasa M, Sato A, Hayashi Y, Tamura A, Yokota A, Ichinohe T, Tohyama K, Hirai H, Maekawa T. Proliferation and differentiation of hematopoietic cells by osteogenic-induced bone marrow MSCs. 第75回日本血液学会学術集会, 札幌, 10月, 2013
  3. Tamura A, Hirai H, Hayashi Y, Yokota A, Yao H, Yoshioka S, Sato A, Iwasa M, Ashihara E, Miura Y, Maekawa T. Involvement of C/EBPβ in the regulation of hematopoietic stem cells. 第75回日本血液学会学術集会, 札幌, 10月, 2013
  4. Yokota A, Hirai H, Hayashi Y, Tamura A, Sato A, Yao H, Yoshioka S, Iwasa M, Ashihara E, Miura Y, Maekawa T. Cytokine-STATs signalings upregulate endogenous C/EBPβ in BCR-ABL+ leukemic cells independently from BCR-ABL signaling. 55th ASH Annual Meeting and Exposition, New Orleans, USA, 12月, 2013
  5. Tamura A, Hirai H, Hayashi Y, Yokota A, Sato A, Yao H, Yoshioka S, Iwasa M, Ashihara E, Miura Y, Maekawa T. Cell-intrinsic and -extrinsic involvement of C/EBPβ in the regulation of hematopoietic stem cells. 55th ASH Annual Meeting and Exposition, New Orleans, USA, 12月, 2013

 

2012年

学会発表

  1. 林嘉宏, 平位秀世, 八尾尚幸, 三浦康生, 芦原英司, 前川平. BCR/ABLの白血病原性における転写因子C/EBPβの関与. 第16回日本がん分子標的治療学会学術総会, 小倉, 6月, 2012
  2. 林嘉宏, 平位秀世, 八尾尚幸, 芦原英司, 前川平. BCR-ABL による C/EBPβの発現亢進が慢性骨髄性白血病の骨髄球系造血亢進および病態進行をもたらす. 第71回日本癌学会学術総会, 札幌, 9月, 2012
  3. Hayashi Y, Hirai H, Tamura A, Yao H, Yoshioka S, Miura Y, Ashihara E, Fujiyama Y, Maekawa T. Involvement of C/EBPβ in the pathogenesis of chronic phase chronic myeloid leukemia. 第74回日本血液学会学術集会, 京都, 10月, 2012
  4. Yao H, Miura Y, Yoshioka S, Hayashi Y, Ashihara E, Hirai H, Maekawa T. Parathyroid hormone stimulates mesenchymal stem cells to enhance expansion of hematopoietic cells. 第74回日本血液学会学術集会, 京都, 10月, 2012
  5. Hayashi Y, Hirai H, Tamura A, Yao H, Yoshioka S, Miura Y, Ashihara E, Fujiyama Y, Tenen DG, Maekawa T. C/EBPβ is upregulated through STAT5 and accelerates exhaustion of leukemic stem cells in chronic phase of chronic myeloid leukemia. 54th ASH Annual Meeting and Exposition, Atlanta, USA, 12月, 2012
  6. Yao H, Miura Y, Yoshioka S, Hayashi Y, Tamura A, Hirai H, Maekawa T. Mesenchymal stem cells skewed their phenotype toward the osteogenic lineage support the hematopoietic cell differentiation. 54th ASH Annual Meeting and Exposition, Atlanta, USA, 12月, 2012
  7. Yoshioka S, Miura Y, Yao H, Hayashi Y, Tamura A, Ichinohe T, Hirai H, Takaori-Kondo A, Maekawa T. Expression of C/EBPβ in Bone Marrow Mesenchymal Stem Cells Is Mandatory for Early-Stage B Cell Lymphopoiesis. 54th ASH Annual Meeting and Exposition, Atlanta, USA, 12月, 2012
  8. Tamura A, Hirai H, Hayashi Y, Yao H, Yoshioka S, Miura Y, Ashihara E, Maekawa T. C/EBPβ-mediated expansion of hematopoietic stem/progenitors precedes ‘emergency’ granulopoiesis induced by candidemia. 54th ASH Annual Meeting and Exposition, Atlanta, USA, 12月, 2012

 

2011年

学術論文

  1. Yao H, Ashihara E, Strovel JW, Nakagawa Y, Kuroda J, Nagao R, Tanaka R, Yokota A, Takeuchi M, Hayashi Y, Shimazaki C, Taniwaki M, Strand K, Padia J, Hirai H, Kimura S, Maekawa T. AV-65, a novel Wnt/β -catenin signal inhibitor, successfully suppresses progression of multiple myeloma in a mouse model. Blood Cancer Journal 1:e43, 2011
  2. Nagao R, Ashihara E, Kimura S, Strovel JW, Yao H, Takeuchi M, Tanaka R, Hayashi Y, Hirai H, Padia J, Strand K, Maekawa T. Growth inhibition of imatinib-resistant CML cells with the T315I mutation and hypoxia-adaptation by AV65--a novel Wnt/β-catenin signaling inhibitor. Cancer Letters 312(1): 91-100, 2011
  3. Tanaka R, Kimura S, Ashihara E, Yoshimura M, Takahashi N, Wakita H, Itoh K, Nishiwaki K, Suzuki K, Nagao R, Yao H, Hayashi Y, Satake S, Hirai H, Sawada K, Ottmann OG, Melo JV, Maekawa T. Rapid automated detection of ABL kinase domain mutations in imatinib-resistant patients. Cancer Letters 312(2): 228-234, 2011
  4. Takeuchi M, Ashihara E, Yamazaki Y, Kimura S, Nakagawa Y, Tanaka R, Yao H, Nagao R, Hayashi Y, Hirai H, Maekawa T. Rakicidin A effectively induces apoptosis in hypoxia adapted Bcr-Abl positive leukemic cells. Cancer Science 102(3): 591-596, 2011

学会発表

  1. Hayashi Y, Hirai H, Kamio N, Yao H, Satake S, Nagao R, Miura Y, Ashihara E, Maekawa T. AV-65 inhibited the growth of myeloma cells by enhancing β-TrCP-mediated β-catenin ubiquitination. 73回日本血液学会学術集会, 名古屋, 10月, 2011
  2. Yao H, Ashihara E, Nagao R, Hayashi Y, Miura Y, Hirai H, Maekawa T. Involvement of C/EBPβ in BCR/ABL-dependent leukemogenesis. 73回日本血液学会学術集会, 名古屋, 10月, 2011
  3. Hayashi Y, Hirai H, Yao H, Yoshioka S, Miura Y, Ashihara E, Fujiyama Y, Tenen DG, Maekawa T. BCR/ABL mediated myeloid expansion is promoted by C/EBPβ, a regulator of emergency granulopoiesis. 53rd ASH Annual Meeting and Exposition, San Diego, USA, 12月, 2011
  4. Yao H, Miura Y, Yoshioka S, Hayashi Y, Hirai H, Maekawa T. Parathyroid hormone stimulates human mesenchymal stem cells to enhance the expansion of hematopoietic stem cells. 53rd ASH Annual Meeting and Exposition, San Diego, USA, 12月, 2011