研究業績

2016 - 2020

 

2020年

学術論文

  1. Harada Y, Shingai N, Ding Y, Sadato D, Hayashi Y, Yamaguchi M, Okuyama Y, Shimoyama T, Ohashi K, Harada H. Gene Rearrangements of MLL and RUNX1 Sporadically Occur in Normal CD34+ Cells Under Cytokine Stimulation. Cancer Science 111(5): 1851-1855, 2020
  2. Takeuchi Y, Tanaka M, Okura N, Fukui Y, Noguchi K, Hayashi Y, Torii T, Ooizumi H, Ohbuchi K, Mizoguchi K, Miyamoto Y, Yamauchi J. Rare Neurologic Disease-Associated Mutations of AIMP1 are Related with Inhibitory Neuronal Differentiation Which is Reversed by Ibuprofen. Medicines 7(5):25, 2020
  3. Sato A, Kamio N, Yokota A, Hayashi Y, Tamura A, Miura Y, Maekawa T, Hirai H. C/EBPβ isoforms sequentially regulate regenerating mouse hematopoietic stem/progenitor cells. Blood Advances 4(14): 3343-3356, 2020
  4. Ogawa K, Asano K, Yotsumoto S, Yamane T, Arita M, Hayashi Y, Harada H, Makino-Okamura C, Fukuyama H, Kondo K, Yamasoba T, Tanaka M. Conversion of neutrophils into atypical Ly6G+ SiglecF+ immune cells with neurosupportive potential in olfactory neuroepithelium. Journal of Leukocyte Biology 109(3): 481-496. 2020

総説

  1. 林嘉宏，原田浩徳. 骨髄異形成症候群の病態形成における自然免疫系制御異常の役割. 造血器腫瘍学（第2版） pp378-383，日本臨床，東京，8月，2020年
  2. 林嘉宏，原田浩徳. 造血器腫瘍におけるHIF1A/ARNTシグナル経路とがん幹細胞制御. 医学のあゆみ 273(5): 404409，2020年

学会発表

  1. 林嘉宏，青栁泰成，原田浩徳. ミトコンドリアダイナミクス異常による骨髄不全症発症機序の解明. 第1回日本癌学会若手の会，熱海，2月，2020年

 

2019年

学術論文

  1. Hayashi Y, Yokota A, Harada H, Huang G. Hypoxia / Pseudohypoxia-mediated Activation of HIF1A in Cancer. Cancer Science. 110(5):1510-1517, 2019
  2. Yokota A, Hirai H, Sato R, Adachi H, Sato F, Hayashi Y, Sato A, Kamio N, Miura Y, Nakano M, Tenen DG, Kimura S, Tashiro K, Maekawa T. C/EBPβ is a critical mediator of IFN-α-induced exhaustion of chronic myeloid leukemia stem cells. Blood Advances 3(3): 476-488, 2019
  3. Dong Y, Zhao X, Feng X, Zhou Y, Yan X, Zhang Y, Bu J, Zhan D, Hayashi Y, Zhang Y, Xu Z, Huang R, Wang J, Zhao T, Xiao Z, Ju Z, Andreassen PR, Wang QF, Chen W, Huang G. SETD2 mutations confer chemoresistance in acute myeloid leukemia partly through altered cell cycle checkpoints. Leukemia 33(11): 2585-2598, 2019
  4. Hayashi Y, Harada Y, Kagiyama Y, Nishikawa S, Ding Y, Imagawa J, Shingai N, Kato N, Kitaura J, Hokaiwado S, Maemoto Y, Ito A, Matsui H, Kitabayashi I, Iwama A, Komatsu N, Kitamura T, Harada H. NUP98-HBO1-Fusion Generates Phenotypically and Genetically Relevant Chronic Myelomonocytic Leukemia Pathogenesis. Blood Advances 3(7): 1047-1060, 2019

総説

  1. 林嘉宏. 骨髄異形成症候群の病態におけるHIF1Aの役割. 臨床血液. 60(7): 818-823, 2019

学会発表

  1. 林嘉宏，新谷直樹，鍵山侑希，原田結花，原田浩徳. MDS with fibrosisの臨床および分子生物学的病態解明. 第23回造血器腫瘍研究会，金沢，1月，2019
  2. 青栁泰成，林嘉宏，新谷直樹，原田結花，原田浩徳. 骨髄不全症をきたす骨髄異形成症候群におけるミトコンドリア電子伝達系制御異常の役割. 第78回日本癌学会学術総会，京都，9月，2019
  3. 新谷直樹, 原田 浩徳, 原田 結花, 林嘉宏, 茅野 秀一, 小松 則夫. 骨髄線維化を伴う骨髄異形成症候群での巨核球集簇の意義. 第81回日本血液学会学術集会，東京，10月，2019
  4. 林嘉宏, 青栁泰成, 新谷直樹, 原田結花, 原田浩徳. ミトコンドリア電子伝達系制御異常によるMDS骨髄不全症の発症機序. 第81回日本血液学会学術集会，東京，10月，2019
  5. Sato A, Yokota A, Hayashi Y, Kamio N, Sagai S, Maekawa T, Hirai H. C/EBPβ Isoforms Regulate Proliferation and Differentiation of Regenerating Hematopoietic Stem/Progenitor Cells. The 61st ASH Annual Meeting and Exposition, Orlando, FL, USA,12月，2019
  6. Ogawa K, Asano K, Yotsumoto S, Yamane T, Arita M, Hayashi Y, Harada H, Fukuyama H, Tanaka M. Neutrophil convert into atypical Ly6G+SiglecF+ cells with neurosupportive properties in olfactory neuroepithelium. 第48回日本免疫学会学術集会，浜松，12月，2019

 

2018年

学術論文

  1. Hayashi Y, Zhang Y, Yokota A, Yan X, Liu J, Choi K, Li B, Sashida G, Peng Y, Xu Z, Huang R, Zhang L, Freudiger GM, Wang J, Dong Y, Zhou Y, Wang J, Wu L, Bu J, Chen A, Zhao X, Sun X, Chetal K, Olsson A, Watanabe M, Romick-Rosendale LE, Harada H, Shih LY, Tse W, Bridges JP, Caligiuri MA, Huang T, Zheng Y, Witte DP, Wang QF, Qu CK, Salomonis N, Grimes HL, Nimer SD, Xiao Z, Huang G. Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes. Cancer Discovery 8(11): 1438-1457, 2018
  2. Wang J, Hayashi Y（共同第一著者）, Yokota A, Xu Z, Zhang Y, Huang R, Yan X, Liu H, Ma L, Azam M, Bridges JP, Cancelas JA, Kalfa TA, An X, Xiao Z, Huang G. Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models. Haematologica 103(1): 40-50, 2018
  3. Bu J, Chen A, Yan X, He F, Dong Y, Zhou Y, He J, Zhan D, Lin P, Hayashi Y, Sun Y, Zhang Y, Xiao Z, Grimes HL, Wang QF, Huang G*. SETD2-mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia. Leukemia 32(4): 890-899, 2018
  4. Zhou Y, Yan X, Feng X, Bu J, Dong Y, Lin P, Hayashi Y, Huang R, Olsson A, Andreassen PR, Grimes HL, Wang QF, Cheng T, Xiao Z, Jin J, Huang G*. Setd2 regulates quiescence and differentiation of adult hematopoietic stem cells by restricting RNA polymerase II elongation. Haematologica 103(7): 1110-1123, 2018

シンポジウム

  1. Hayashi Y. HIF1A pathway as a signaling funnel for MDS-driver mutations. 第80回日本血液学会学術集会，シンポジウム「Rising Star in JSH」. 大阪, 10月，2018

学会発表

  1. 林嘉宏, 原田結花, 丁曄, 松井啓隆, 鍵山侑希, 加藤菜穂子, 北林一生, 岩間厚志, 北村俊雄,原田浩徳. ヒストンアセチル化制御破綻による慢性骨髄単球性白血病の新規発症機序の解明. 第22回造血器腫瘍研究会，横浜，1月，2018
  2. Hayashi Y, Harada Y, Matsui H, Kato N, Ding Y, Kagiyama Y, Kitabayashi I, Iwama A, Kitamura T, Harada H. NUP98-HBO1 Induces Phenotypically and Genetically Relevant Chronic Myelomonocytic Leukemia Pathogenesis through Aberrant Histone Acetylation. 12th International Workshop on Molecular Aspects On Myeloid Stem Cell Development And Leukemia, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA, 5月, 2018
  3. Sato A, Yokota A, Hayashi Y, Tamura A, Miura Y, Maekawa T, Hirai H. C/EBPβ isoforms sequentially regulate proliferation and differentiation of regenerating hematopoietic stem/progenitor cells. 12th International Workshop on Molecular Aspects On Myeloid Stem Cell Development And Leukemia, Cincinnati Children’s Hospital Medical Center, Cincinnati, OHo, USA, 5月, 2018
  4. Yokota A, Hirai H, Hayashi Y, Sato A, Sato R, Adachi H, Sato F, Miura Y, Nakano M, Kimura S, Tashiro K, Maekawa T. C/EBPβ Critically Mediates IFNα-Induced Exhaustion of Chronic Myeloid Leukemia Stem Cells. 第9回JSH国際シンポジウム，京都，7月，2018
  5. Harada Y, Hayashi Y, Kagiyama Y, Matsui H, Kitabayashi I, Iwama A, Kitamura T, Harada H. NUP98-HBO1 Induces Clinically Relevant Chronic Myelomonocytic Leukemia Pathogenesis through Aberrant Histone Acetylation. ISEH 46th Annual Scientific Meeting, Los Angeles, CA, USA, 8月, 2018
  6. Hayashi Y, Harada Y, Kagiyama Y, Shingai N, Komatsu N, Matsui H, Kitabayashi I, Iwama A, Kitamura T, Harada H. Aberrant Histone Acetylation by HBO-1 fusion Generates Clinically Relevant Chronic Myelomonocytic Leukemia Pathogenesis. 第77回日本癌学会学術総会，大阪, 9月, 2018
  7. Hayashi Y, Harada Y, Kagiyama Y, Matsui H, Kato N, Ding Y, Imagawa J, Kitaura J, Kitabayashi I, Iwama A, Kitamura T, Harada H. NUP98-HBO1 Induces Clinically Relevant CMML Pathogenesis through Aberrant Histone Acetylation. 第80回日本血液学会学術集会，大阪, 10月, 2018
  8. Tang Y, Yan X, Zhan D, Wen L, Huang R, Zhang Y, Hayashi Y, Wang QF, Zhou J, Huang G. Myc Regulates the Development and Anti-Tumor Immunity of Natural Killer Cells. 60th ASH Annual Meeting and Exposition, San Diego, CA, USA, 12月, 2018
  9. Wang C, Hayashi Y, Cai X, Yan X, Huang G, Zheng Y. Inducible Correction of a RUNX1 Mutation of Human AML Causes a Switch of AML to B-ALL. 60th ASH Annual Meeting and Exposition, San Diego, CA, USA, 12月, 2018
  10. Yokota A, Zhang L, Yan X, Feng X, Wen L, Freudiger G, Rife M, Woeste A, Hayashi Y, Huang G. Mll-Partial Tandem Duplication (Mll-PTD) Causes Pseudohypoxia and Hypermethylation of the Epigenome through Suppression of Mitochondrial Complex II. 60th ASH Annual Meeting and Exposition, San Diego, CA, USA, 12月, 2018

その他

  1. 林嘉宏. 骨髄異形成症候群におけるHIF1Aシグナルの亢進―治療標的としての可能性―. 第22回日本がん分子標的治療学会学術集会，ランチョンセミナー，東京，5月，2018

 

2017年

学術論文

  1. Huang R, Hayashi Y（共同第一著者）, Yan X, Bu J, Wang J, Zhang Y, Zhou Y, Tang Y, Wu L, Xu Z, Liu X, Wang Q, Zhou J, Xiao Z, Bridges JP, Marsh RA, Zhang K, Jordan MB, Li Y, Huang G. HIF1A is a critical downstream mediator for hemophagocytic lymphohistiocytosis. Haematologica 102(11): 1956-1968, 2017
  2. Hayashi Y, Harada Y, Huang G, Harada H. Myeloid neoplasms with germ line RUNX1 mutation. International Journal of Hematology 106(2):183-188, 2017

学会発表

  1. Hayashi Y, Zhang Y, Yan X, Sashida G, Chetal K, Olsson A, Harada H, Shih LY, Tse W, Bridges JP, Zheng Y, Witte D, Caligiuri MA, Qu CK, Wang Q, Salomonis N, Grimes HL, Nimer SD, Xiao Z, Huang G. HIF1A signaling is a central pathobiologic mediator of MDS. The 14th International Symposium on Myelodysplastic Syndromes, Valencia, Spain, 5月, 2017
  2. Yokota A, Hirai H, Sato A, Hayashi Y, Miura Y, Kimura S, Maekawa T. Exhaustion of CD34+ CML-CP stem cells is induced by IFNα through upregulation of C/EBPβ. 第76回日本癌学会学術総会, 東京, 9月, 2017
  3. Hayashi Y, Zhang Y, Yan X, Sashida G, Chetal K, Olsson A, Harada H, Shih LY, Tse W, Bridges JP, Zheng Y, Witte D, Caligiuri MA, Qu C, Wang Q, Salomonis N, Grimes HL, Nimer SD, Xiao Z, Huang G. Identification of HIF1A signaling as a critical mediator of MDS pathogenesis. 第79回日本血液学会学術集会, 東京, 10月, 2017
  4. Yokota A, Hirai H, Sato A, Kamio N, Shoji T, Kashiwagi T, Torikoshi Y, Miura Y, Hayashi Y, Kimura S, Maekawa T. IFNα upregulates C/EBPβ in CD34+ CML stem cells and induces their exhaustion. 第79回日本血液学会学術集
  5. Yokota A, Hayashi Y, Wang J, Huang R, Yan X, Zhang Y, Huang G. Monocytes/Macrophages are involved in erythrocytosis caused by both EPO-dependent and -independent activation of EPOR. 59th ASH Annual Meeting and Exposition, Atlanta, GA, USA, 12月, 2017
  6. Yokota A, Hirai H, Sato A, Kamio N, Hayashi Y, Miura Y, Kimura S, Maekawa T. IFN-α Upregulates the Expression of C/EBPβ and Induces Myeloid Differentiation and Exhaustion of CD34+ CML Stem Cells. 59th ASH Annual Meeting and Exposition, Atlanta, GA, USA, 12月, 2017
  7. Hayashi Y, Huang R, Yan X, Bu J, Wang J, Zhang Y, Zhou Y, Tang Y, Wu L, Xu Z, Liu X, Wang Q, Zhou J, Xiao Z, Bridges JP, Marsh RA, Zhang K, Jordan MB, Li Y, Huang G. HIF1A Is a Critical Downstream Mediator for Hemophagocytic Lymphohistiocytosis. 59th ASH Annual Meeting and Exposition, Atlanta, GA, USA, 12月, 2017

 

2016年

学会発表

  1. 横田明日美、平位秀世、林嘉宏, 前川平. 慢性骨髄性白血病の病態形成における転写因子C/EBPβの機能. 第20回造血器腫瘍研究会, 千葉, 2月, 2016
  2. Hayashi Y, Zhang Y, Yan X, Choi K, Sashida G, Dong Y, Xu Z, Wu L, Chen A, Sun X, Olsson A, Harada H, Shih LY, Tse W, Bridges JP, Witte D, Wang J, Caligiuri M, Grimes HL, Nimer SD, Xiao Z, Huang G. All Roads Lead to Rome: MDS-associated mutations activate HIF-1α signaling. Eleventh international workshop on molecular aspects of myeloid stem cell development and leukemia, Cincinnati, OH, USA, 5月, 2016
  3. Yokota A, Hirai H, Hayashi Y, Sato R, Adachi H, Sato F, Sato A, Tamura A, Iwasa M, Fujishiro A, Shoji T, Kashiwagi T, Miura Y, Nakano M, Tashiro K, Maekawa T. The C/EBPβ Transcription Factor Mediates the Effect of IFNα on CML Stem Cells Through Promoting Their Differentiation and Exhaustion. The 5th JCA-AACR Special Joint Conference, Maihama, Japan, 7月, 2016
  4. Huang G, Huang R, Hayashi Y, Yan X, Jordan MB, Filipovich AH. Blood specific activation of HIF-1α/HIF-1β causes HLH immunopathology in C57BL/6 mice. 32nd Annual Meeting of the Histiocyte Society, Dublin, Ireland, 10月, 2016
  5. Yokota A, Hirai H, Sato A, Tamura A, Shoji T, Kashiwagi T, Fujishiro A, Iwasa M, Miura Y, Hayashi Y, Maekawa T. The C/EBPβ transcription factor mediates exhaustion of CML stem cells induced by IFNα. 第78回日本血液学会学術集会, プレナリーセッション, 横浜, 10月, 2016
  6. Yokota A, Hirai H, Hayashi Y, Sato R, Adachi H, Sato F, Sato A, Tamura A, Miura Y, Nakano M, Tashiro K, Maekawa T. The C/EBPβ transcription factor promotes exhaustion of CML stem cells in response to interferon-α. 第75回日本癌学会学術総会, 横浜, 10月, 2016
  7. Hayashi Y, Wang J, Xu Z, Yan X, Zhang Y, Kalfa TA, Xiao Z, Huang G. EPO Signaling Triggers Erythrocytosis By Expanding Erythrocytes and Also Subsets of Macrophages. 58th ASH Annual Meeting and Exposition, San Diego, CA, USA, 12月, 2016
  8. Yokota A, Hirai H, Hayashi Y, Sato R, Adachi H, Sato F, Sato A, Tamura A, MD, Iwasa M, Fujishiro A, Shoji T, Kashiwagi T, Kamio N, Torikoshi Y, Miura Y, Nakano M, Tashiro K, Maekawa T. C/EBPβ Is a Critical Regulator of CML Stem Cell Differentiation and Exhaustion Induced By Interferon-α. 58th ASH Annual Meeting and Exposition, San Diego, CA, USA, 12月, 2016
  9. Bu J, Chen A, Dong Y, He F, Yan X, Zhou Y, Zhan D, Hayashi Y, Wang Q, Huang G. Downregulation of SETD2-H3K36me3 Tumor Suppression Axis Promotes MLL Leukemia through Activation of DOT1L-H3K79me2 Axis. 58th ASH Annual Meeting and Exposition, San Diego, CA, USA, 12月, 2016
  10. Zhou Y, Dong Y, Bu J, Yan X, Hayashi Y, Wang Q, Jin J, Huang G. SETD2, a H3K36 Lysine Methyltransferase, Is Essential for Adult Normal Hematopoiesis and Leukemia Stem Cells. 58th ASH Annual Meeting and Exposition, San Diego, CA, USA, 12月, 2016
  11. Huang R, Hayashi Y, Yan X, Jordan M, Huang G. Activation of HIF Signaling in Mononuclear Phagocyte System Causes Hemophagocytic Lymphohistiocytosis in C57/BL6 Mice. 58th ASH Annual Meeting and Exposition, San Diego, CA, USA, 12月, 2016
  12. Cai X, Hayashi Y, Wunderlich M, Speck NA, Mulloy JC, Huang G, Zheng Y. Loss of Function RUNX1 Mutations Restrict Protein Biosynthesis during Pre-Leukemia and MDS Transition but Not after Leukemic Transformation. 58th ASH Annual Meeting and Exposition, San Diego, CA, USA, 12月, 2016